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Trifluoromethyl ketones as inhibitors of histone deacetylase.

Abstract：

:Trifluoromethyl ketones were found to be inhibitors of histone deacetylases (HDACs). Optimization of this series led to the identification of submicromolar inhibitors such as 20 that demonstrated antiproliferative effects against the HT1080 and MDA 435 cell lines.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Frey RR,Wada CK,Garland RB,Curtin ML,Michaelides MR,Li J,Pease LJ,Glaser KB,Marcotte PA,Bouska JJ,Murphy SS,Davidsen SK

doi

10.1016/s0960-894x(02)00754-0

subject

Has Abstract

pub_date

2002-12-02 00:00:00

pages

3443-7

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960894X02007540

journal_volume

12

pub_type

杂志文章

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