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Chemoenzymatic deacylation of ramoplanin.

Abstract：

:The chemoenzymatic deacylation of ramoplanin A2 is described for the first time: ramoplanin A2 was Boc-protected and hydrogenated to Boc-protected tetrahydroramoplanin, which was subsequently deacylated using an acylase from Actinoplanes utahensis NRRL 12052. The chemoenzymatic process proceeded with 80% overall yield, which favourably compares with the previously described chemical deacylation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Gandolfi R,Marinelli F,Ragg E,Romano D,Molinari F

doi

10.1016/j.bmcl.2012.06.046

subject

Has Abstract

pub_date

2012-08-15 00:00:00

pages

5283-7

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00797-4

journal_volume

22

pub_type

杂志文章

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