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Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors.

Abstract：

:A few naturally occurring prenyl- and prenyloxycoumarins and several new related synthetic derivatives were evaluated as inhibitors of squalene-hopene cyclase (SHC), a useful model enzyme, to predict their interactions with oxidosqualene cyclase (OSC). Umbelliprenin-10',11'-monoepoxide (IC(50) 2.5 microM) and the corresponding 6',7'-10',11' diepoxide (IC(50) 1.5 microM) were the most active enzyme inhibitors.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Cravotto G,Balliano G,Robaldo B,Oliaro-Bosso S,Chimichi S,Boccalini M

doi

10.1016/j.bmcl.2004.01.085

subject

Has Abstract

pub_date

2004-04-19 00:00:00

pages

1931-4

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960894X04001647

journal_volume

14

pub_type

杂志文章

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