当前位置： SCI文献检索 > BIOORGANIC & MEDICINAL CHEMISTRY LETTERS期刊下所有文献 > Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

Abstract：

:By performing RNA-targeted structure-activity relationship studies, we discovered a novel peptidomimetic containing squaryldiamide as a potential bioisostere replacement for guanidine that binds transactivation responsive RNA with high affinity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lee CW,Cao H,Ichiyama K,Rana TM

doi

10.1016/j.bmcl.2005.06.077

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

4243-6

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00840-1

journal_volume

15

pub_type

杂志文章

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