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Synthesis, structural characterization and antitumor activity evaluations of copper complex with tetraazamacrocyclic ligand.

Abstract：

:Cu (II) complex with 1,4,7,10-tetrakis(2-cyanoethyl-)-1,4,7,10-tetraazacyclododecane was prepared and characterized by X-ray diffraction. Four nitrogen atoms of macrocyclic ligand and oxygen atom of water molecule defined a tetragonal pyramidal polyhedron surrounding the central copper atom. Preliminary pharmacological tests showed that it had antitumor activity against P388 and BEL-7404 cell lines in vitro. Also it exhibited perturbation effects to K562 tumor cell lines at G0-G1 stage and further studies showed that it can cleave supercoiled DNA (pBR 322) to nicked and linear DNA in aerobic condition.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kong D,Qin C,Meng L,Xie Y

doi

10.1016/s0960-894x(99)00139-0

subject

Has Abstract

pub_date

1999-04-19 00:00:00

pages

1087-92

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960894X99001390

journal_volume

9

pub_type

杂志文章

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