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Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.

Abstract：

:A small set of 9-aminoacridine-3- and 4-carboxamides were synthesized efficiently using the benzyne/azide click chemistry. The products bind to duplex DNA but have different antitumour activity in the HL60 cell line.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Howell LA,Howman A,O'Connell MA,Mueller A,Searcey M

doi

10.1016/j.bmcl.2009.08.070

subject

Has Abstract

pub_date

2009-10-15 00:00:00

pages

5880-3

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01216-5

journal_volume

19

pub_type

杂志文章

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