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Trifluoromethylation of flavonoids and anti-tumor activity of the trifluoromethylated flavonoid derivatives.

Abstract：

:3-Trifluoromethylflavonoid derivatives were prepared for the first time by trifluoromethylation of 3-iodoflavonoid derivatives. Other C ring and B ring trifluoromethylated flavonoid derivatives were also prepared. All the compounds were tested for their effect on the U2OS cell cycle in vitro. Bistrifluoromethylated apigenin derivative 13 showed the strongest activity against the cell growth.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wang CL,Li HQ,Meng WD,Qing FL

doi

10.1016/j.bmcl.2005.07.047

subject

Has Abstract

pub_date

2005-10-15 00:00:00

pages

4456-8

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00930-3

journal_volume

15

pub_type

杂志文章

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