Syntheses and anti-inflammatory activity of azamollugin derivatives.

Abstract:

:Oxomollugin (2) is a degradation product of mollugin (1) and a potent inhibitor of NO-production including nuclear factor kappa B signals. In our endeavor to develop a potent anti-inflammatory compound, we synthesized several aza-derivatives of oxomollugin (2) and evaluated their NO-production inhibitory activity. Azamollugin (3) showed a potent inhibitory activity, and its activity (IC50 0.34μM) was proved to be more potent than that of oxomollugin (2, IC50 1.3μM).

journal_name

Bioorg Med Chem Lett

authors

Nishino H,Nakajima Y,Kakubari Y,Asami N,Deguchi J,Nugroho AE,Hirasawa Y,Kaneda T,Kawasaki Y,Goda Y,Morita H

doi

10.1016/j.bmcl.2015.11.081

subject

Has Abstract

pub_date

2016-01-15 00:00:00

pages

524-525

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30289-4

journal_volume

26

pub_type

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