Multidrug resistance-reversal effects of resin glycosides from Dichondra repens.

Abstract:

:Investigation of hydrophobic extract of Dichondra repens (Convolvulaceae) led to the isolation of three new resin glycosides dichondrins A-C (1-3), and three known resin glycosides cus-1, cus-2, and cuse 3. All the isolated resin glycosides with an acyclic core were evaluated for their multidrug resistance reversal activities, and the combined use of these compounds at a concentration of 25μM increased the cytotoxicity of vincristine by 1.03-1.78-fold.

journal_name

Bioorg Med Chem Lett

authors

Song WB,Wang WQ,Zhang SW,Xuan LJ

doi

10.1016/j.bmcl.2014.12.083

subject

Has Abstract

pub_date

2015-02-15 00:00:00

pages

795-8

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)01391-2

journal_volume

25

pub_type

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