Abstract:
:A series of alpha(v)beta(3) antagonists based on a thiophene scaffold were synthesized via two routes and evaluated for in vitro biological activity. We have identified several structurally similar antagonists with different selectivities towards alpha(IIb)beta(3), alpha(v)beta(5) and alpha(5)beta(1) at the cellular level. In addition, these antagonists exerted an antiangiogenic effect in the chick chorioallantoic membrane (CAM) assay.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Bubenik M,Meerovitch K,Bergeron F,Attardo G,Chan Ldoi
10.1016/s0960-894x(02)00942-3subject
Has Abstractpub_date
2003-02-10 00:00:00pages
503-6issue
3eissn
0960-894Xissn
1464-3405pii
S0960894X02009423journal_volume
13pub_type
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