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PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics.

Abstract：

:Out of 400 virtually designed imidazoline N-oxides, five cyclic nitrones were selected on the basis of PASS prediction as potent nootropics and were evaluated for their biological activities in albino mice. The selected N-alkyl and aryl-substituted nitrones were found to be excellent nootropics. A series of lead compounds acting as cognition enhancers have been provided, which can be further exploited in search of such New Chemical Entities (NCEs).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Marwaha A,Goel RK,Mahajan MP

doi

10.1016/j.bmcl.2007.06.071

subject

Has Abstract

pub_date

2007-09-15 00:00:00

pages

5251-5

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00766-4

journal_volume

17

pub_type

杂志文章

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