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1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes.

Abstract：

:The 1,2,3-triazole ring fused with pyridine/pyrimidine was explored as new template for the identification of potential antimicrobial agents. The regioselective synthesis of these pre-designed N-heteroarenes was achieved via exploring the application of Buchwald's strategy (i.e. C-N bond formation/reduction/diazotization/cyclization sequence) to the N-heteroarene system. Two of them showed promising antibacterial (comparable to streptomycin) and several showed potent antifungal (comparable to mancozeb) activities.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Marepu N,Yeturu S,Pal M

doi

10.1016/j.bmcl.2018.09.021

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

3302-3306

issue

20

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(18)30752-2

journal_volume

28

pub_type

杂志文章

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