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Improved performance by replacing iminodiacetic residues with glyceryl residues in symmetrically branched oligoglycerols.

Abstract：

:Synthesis of a symmetrically branched diglycerol (BGL002, involving one iminodiacetic residue) as a G2 dendron, and the tetradecaglycerol (BGL014, involving one iminodiacetic residue) as a G4 dendron, is described. Several members of the BGL family of G2-G4 dendrons were assembled, with G2 bearing four hydroxyl groups at the terminus region, G3 bearing eight, and G4 bearing sixteen. It is noteworthy that triglycerol (BGL003, including no iminodiacetic residue), has a water-solubility ten times higher than BGL002, and the liposome surrounded by BGL014 has a duration period in blood vessel roughly two times longer than the liposome surrounded by dodecaglycerol (BGL012, including three iminodiacetic residues).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Nemoto H,Ishihara A,Araki T,Katagiri A,Kamiya M,Matsushita T,Hattori H,Mimura Y,Tomoda Y,Yamasaki M

doi

10.1016/j.bmcl.2011.06.064

subject

Has Abstract

pub_date

2011-08-15 00:00:00

pages

4724-7

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00847-X

journal_volume

21

pub_type

杂志文章

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