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One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents.

Abstract：

:2-Propargylthiobenzimidazole 1, 4-bromomethyl coumarins/1-aza-coumarins 2/3 and sodium azide have been reacted in one pot under Click chemistry conditions to give exclusively 1,4-disubstituted triazoles 5a-n. Anti-tubercular assays against M. tuberculosis (H37Rv) coupled with in silico molecular docking studies indicated that dimethyl substituents 5c and 5d showed promising activity with higher C-score values.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Anand A,Kulkarni MV,Joshi SD,Dixit SR

doi

10.1016/j.bmcl.2016.08.045

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

4709-4713

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(16)30866-6

journal_volume

26

pub_type

杂志文章

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