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Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin.

Abstract：

:The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yamamoto M,Ikeda S,Kondo H,Inoue S

doi

10.1016/s0960-894x(01)00755-7

subject

Has Abstract

pub_date

2002-02-11 00:00:00

pages

375-8

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960894X01007557

journal_volume

12

pub_type

杂志文章

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