Abstract:
:(+)-proto-Quercitol (1) and (-)-vibo-quercitol (2), both of which could be readily prepared by the bioconversion of myo-inositol, were successfully converted into the corresponding 4-methylenecyclohex-5-ene-1,2,3-triol derivatives. These compounds were demonstrated to be suitable precursors, preserving their configurations, for bioactive carba-aminosugars such as the potent chemical chaperone drug candidates, N-octyl-4-epi-β-valienamine (NOEV, 3) and N-octyl-β-valienamine (NOV, 4).
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Kuno S,Takahashi A,Ogawa Sdoi
10.1016/j.bmcl.2011.09.067subject
Has Abstractpub_date
2011-12-01 00:00:00pages
7189-92issue
23eissn
0960-894Xissn
1464-3405pii
S0960-894X(11)01311-4journal_volume
21pub_type
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