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Nitrone derivatives of trolox as neuroprotective agents.

Abstract：

:Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe(2+)-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Balogh GT,Vukics K,Könczöl A,Kis-Varga A,Gere A,Fischer J

doi

10.1016/j.bmcl.2005.04.043

subject

Has Abstract

pub_date

2005-06-15 00:00:00

pages

3012-5

issue

12

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)00525-1

journal_volume

15

pub_type

杂志文章

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