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Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.

Abstract：

:Derivatives of phaeosphaeride A (PPA) were synthesised and characterised; then anti-cancer studies were carried out on the A549 cancer cell line. It was found that the acetyl derivative (compound 3) displayed comparable in vitro cytotoxicity to that of PPA (EC50=49±7 μM and EC50=46±5 μM, respectively), while chloroacetyl derivative 6 (EC50=33±7 μM) was found to have better efficacy towards the A549 cancer cell line.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Abzianidze VV,Prokofieva DS,Chisty LA,Bolshakova KP,Berestetskiy AO,Panikorovskii TL,Bogachenkov AS,Holder AA

doi

10.1016/j.bmcl.2015.10.048

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

5566-9

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)30157-8

journal_volume

25

pub_type

杂志文章

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