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Design and synthesis of Pfmrk inhibitors as potential antimalarial agents.

Abstract：

:The synthesis and inhibitory activities of 10 potential inhibitors of Pfmrk, a Plasmodium falciparum cyclin-dependent protein kinase, are described. The most potent inhibitor is a 3-phenyl-quinolinone compound with an IC(50) value of 18 microM. It is the first compound reported to inhibit Pfmrk at the micro molar range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Xiao Z,Waters NC,Woodard CL,Li Z,Li PK

doi

10.1016/s0960-894x(01)00578-9

subject

Has Abstract

pub_date

2001-11-05 00:00:00

pages

2875-8

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(01)00578-9

journal_volume

11

pub_type

杂志文章

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