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Novel anthraquinone based chalcone analogues containing an imine fragment: synthesis, cytotoxicity and anti-angiogenic activity.

Abstract：

:A new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11μM. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kolundžija B,Marković V,Stanojković T,Joksović L,Matić I,Todorović N,Nikolić M,Joksović MD

doi

10.1016/j.bmcl.2013.11.075

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

65-71

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01366-8

journal_volume

24

pub_type

杂志文章

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