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Convergent solution-phase synthesis of a nucleopeptide using a protected oligonucleotide.

Abstract：

:A nucleopeptide was prepared in a convergent manner via segmental coupling of the protected biopolymers in solution. The resulting nucleopeptide (4b, 72%) containing the binding site of lambda repressor and a peptide containing the consensus sequence of the DNA binding helix of the helix turn-helix-proteins was obtained using only five equivalents of the peptide relative to the oligonucleotide. This demonstrates that the recently developed method for the solution phase coupling of protected oligonucleotides is amenable to the convergent synthesis of larger nucleopeptides that are potentially capable of adopting secondary structure.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

McMinn DL,Greenberg MM

doi

10.1016/s0960-894x(99)00051-7

subject

Has Abstract

pub_date

1999-02-22 00:00:00

pages

547-50

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960894X99000517

journal_volume

9

pub_type

杂志文章

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