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Design of antimicrobial compounds based on peptide structures.

Abstract：

:New antimicrobial compounds are of major importance because of the growing problem of bacterial resistance and antimicrobial peptides have been gaining a lot of interest. Their mechanism of action, however, is often obscure. Here a set of non-peptidic compounds with antimicrobial activity are presented that have been designed based on criteria derived from three-dimensional structures of antimicrobial peptides. Even though only a small set of compounds has been designed, the activity immediately matches that of the original peptides, supporting the proposed criteria for activity, i.e. not the peptidic nature of antimicrobial peptides is responsible for their activity but rather the proper arrangement of the relevant functional groups.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Appelt C,Schrey AK,Söderhäll JA,Schmieder P

doi

10.1016/j.bmcl.2007.01.075

subject

Has Abstract

pub_date

2007-04-15 00:00:00

pages

2334-7

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)00125-4

journal_volume

17

pub_type

杂志文章

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