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The synthesis of xanthones, xanthenediones, and spirobenzofurans: their antibacterial and antifungal activity.

Abstract：

:Exposure of the phenol, (5-bromo-2-hydroxyphenyl)(2,4,5-trimethoxyphenyl)methanone 18 to ceric ammonium nitrate (CAN) resulted in the formation of 7-bromo-3,4a-dimethoxy-2H-xanthene-2,9(4aH)-dione 19 and 5-bromo-2',5'-dimethoxy-3H-spiro[benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione 20. The brominated spirobenzofuran 20 was then subjected to Suzuki-Miyaura reactions to give six derivatives 22a-f. These compounds, related diones and xanthones displayed mostly noteworthy antimicrobial activity, particularly towards the yeasts Cryptococcus neoformans and Candida albicans. Diones 15 and 30 displayed significant activity (7.8 μg/mL) against C. albicans and C. neoformans, respectively. Furthermore, dione 10 displayed the most significant activity (3.6 μg/mL) against both yeasts.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Omolo JJ,Johnson MM,van Vuuren SF,de Koning CB

doi

10.1016/j.bmcl.2011.09.088

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

7085-8

issue

23

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01332-1

journal_volume

21

pub_type

杂志文章

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