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Discovery of a novel class of selective human CB1 inverse agonists.

Abstract：

:Ligand-based virtual screening led to the discovery of a new class of potent inverse agonists of the human cannabinoid receptor 1, hCB(1), which are selective versus hCB(2). These CB(1) ligands present intriguing departures from a classical CB(1) antagonist pharmacophore. Elements of SAR are discussed in this context.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Foloppe N,Allen NH,Bentley CH,Brooks TD,Kennett G,Knight AR,Leonardi S,Misra A,Monck NJ,Sellwood DM

doi

10.1016/j.bmcl.2007.11.133

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

1199-206

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01428-X

journal_volume

18

pub_type

杂志文章

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