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Effects of alkyl parabens on plant pathogenic fungi.

Abstract：

:Alkyl parabens are used as antimicrobial preservatives in cosmetics, food, and pharmaceutical products. However, the mode of action of these chemicals has not been assessed thoroughly. In this study, we determined the effects of alkyl parabens on plant pathogenic fungi. All the fungi tested, were susceptible to parabens. The effect of linear alkyl parabens on plant pathogenic fungi was related to the length of the alkyl chain. In addition, the antifungal activity was correlated with the paraben-induced inhibition of oxygen consumption. The antifungal activity of linear alkyl parabens likely originates, at least in part, from their ability to inhibit the membrane respiratory chain, especially mitochondrial complex II. Additionally, we determined that some alkyl parabens inhibit Alternaria brassicicola infection of cabbage.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Ito S,Yazawa S,Nakagawa Y,Sasaki Y,Yajima S

doi

10.1016/j.bmcl.2015.02.049

subject

Has Abstract

pub_date

2015-04-15 00:00:00

pages

1774-1777

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(15)00169-9

journal_volume

25

pub_type

杂志文章

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