Abstract:
:γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Rydzik AM,Brem J,Struwe WB,Kochan GT,Benesch JL,Schofield CJdoi
10.1016/j.bmcl.2014.09.035subject
Has Abstractpub_date
2014-11-01 00:00:00pages
4954-7issue
21eissn
0960-894Xissn
1464-3405pii
S0960-894X(14)00977-9journal_volume
24pub_type
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