Ejection of structural zinc leads to inhibition of γ-butyrobetaine hydroxylase.

Abstract:

:γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate and Fe(II) dependent oxygenase that catalyses an essential step during carnitine biosynthesis in animals. BBOX is inhibited by ejection of structural zinc by a set of selenium containing analogues. Previous structural analyses indicated that an undisrupted N-terminal zinc binding domain of BBOX is required for catalysis. Ebselen is a relatively potent BBOX inhibitor, an observation which may in part reflect its cardioprotective properties.

journal_name

Bioorg Med Chem Lett

authors

Rydzik AM,Brem J,Struwe WB,Kochan GT,Benesch JL,Schofield CJ

doi

10.1016/j.bmcl.2014.09.035

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

4954-7

issue

21

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(14)00977-9

journal_volume

24

pub_type

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