Yohimbine dimers exhibiting binding selectivities for human alpha2a- versus alpha2b-adrenergic receptors.

Abstract:

:A series of yohimbine dimers was prepared and evaluated at the human alpha2a- and alpha2b-adrenergic receptors (ARs) expressed in Chinese hamster ovary (CHO) cells. All dimers display higher binding selectivities for alpha2a versus alpha2b subtype than yohimbine, and four compounds (3d, 3e, 3g and 3i) represent the most potent and alpha2a versus alpha2b-AR selective ligands identified so far.

journal_name

Bioorg Med Chem Lett

authors

Zheng W,Lei L,Lalchandani S,Sun G,Feller DR,Miller DD

doi

10.1016/s0960-894x(00)00068-8

subject

Has Abstract

pub_date

2000-04-03 00:00:00

pages

627-30

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00068-8

journal_volume

10

pub_type

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