Abstract:
:A series of yohimbine dimers was prepared and evaluated at the human alpha2a- and alpha2b-adrenergic receptors (ARs) expressed in Chinese hamster ovary (CHO) cells. All dimers display higher binding selectivities for alpha2a versus alpha2b subtype than yohimbine, and four compounds (3d, 3e, 3g and 3i) represent the most potent and alpha2a versus alpha2b-AR selective ligands identified so far.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Zheng W,Lei L,Lalchandani S,Sun G,Feller DR,Miller DDdoi
10.1016/s0960-894x(00)00068-8subject
Has Abstractpub_date
2000-04-03 00:00:00pages
627-30issue
7eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00068-8journal_volume
10pub_type
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