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Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin.

Abstract：

:The use of doxorubicin (DOX) in the treatment of solid tumors is limited by cardiotoxicity essentially due to oxidative stress generation. The aim of this study was to identify coumarin derivatives displaying a protective antioxidant activity without affecting DOX antitumoral efficiency. A set of eighteen coumarinic derivatives was synthesized. Their antioxidant power was evaluated in vitro with the FRAP (ferric reducing ability of plasma) method and in human breast adenocarcinoma MCF7 cells using H(2)DCFDA (2',7'-dichlorodihydrofluorescein diacetate) in a cytometric analysis. 4-Methyl-7,8-dihydroxycoumarin was found to exhibit an important antioxidant strength, a low cytotoxicity, and could decrease ROS (reactive oxygen species) production generated by DOX treatment without affecting DOX cytotoxicity in MCF7 cells.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Beillerot A,Domínguez JC,Kirsch G,Bagrel D

doi

10.1016/j.bmcl.2007.12.004

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

1102-5

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(07)01447-3

journal_volume

18

pub_type

杂志文章

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