Abstract:
:Exploration of the indole nitrogen region of Zafirlukast (1) has uncovered a potent series of cysteinyl leukotriene D4 (LTD4) antagonists. These studies showed that a variety of functionality could be incorporated in this region of the molecule without sacrificing potency. Efforts to exploit this site in order to improve oral efficacy are discussed.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Brown MF,Marfat A,Antognoli G,Chambers RJ,Cheng JB,Damon DB,Liston TE,McGlynn MA,O'Sullivan SP,Owens BS,Pillar JS,Shirley JT,Watson JWdoi
10.1016/s0960-894x(98)00442-9subject
Has Abstractpub_date
1998-09-22 00:00:00pages
2451-6issue
18eissn
0960-894Xissn
1464-3405pii
S0960894X98004429journal_volume
8pub_type
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journal_title:Bioorganic & medicinal chemistry letters
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