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Synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents.

Abstract：

:A series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four Gram-positive bacteria (Staphylococcus aureus, MRSA, Bacillus subtilis and Micrococcus luteus), four Gram-negative bacteria (Escherichia coli, Proteus vulgaris, Salmonella typhi and Shigella dysenteriae) as well as three fungi (Candida albicans, Saccharomyces cerevisiae and Aspergillus fumigatus) by two-fold serial dilution technique. The bioactive assay showed that some synthesized coumarin triazoles displayed comparable or even better antibacterial and antifungal efficacy in comparison with reference drugs Enoxacin, Chloromycin and Fluconazole. Coumarin bis-triazole compounds exhibited stronger antibacterial and antifungal efficiency than their corresponding mono-triazole derivatives.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shi Y,Zhou CH

doi

10.1016/j.bmcl.2010.12.059

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

956-60

issue

3

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01823-8

journal_volume

21

pub_type

杂志文章

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