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Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives.

Abstract：

:We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4×10(-6)-1.2×10(-7) M.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Matsumoto K,Choshi T,Hourai M,Zamami Y,Sasaki K,Abe T,Ishikura M,Hatae N,Iwamura T,Tohyama S,Nobuhiro J,Hibino S

doi

10.1016/j.bmcl.2012.05.064

subject

Has Abstract

pub_date

2012-07-15 00:00:00

pages

4762-4

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(12)00667-1

journal_volume

22

pub_type

杂志文章

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