Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors.

Abstract:

:Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1, -3, and -5.

journal_name

Bioorg Med Chem Lett

authors

Lim HS,Oh YS,Suh PG,Chung SK

doi

10.1016/s0960-894x(02)00893-4

subject

Has Abstract

pub_date

2003-01-20 00:00:00

pages

237-40

issue

2

eissn

0960-894X

issn

1464-3405

pii

S0960894X02008934

journal_volume

13

pub_type

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