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Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing.

Abstract：

:Over-expressions of miRNAs are being increasingly linked with many diseases including different types of cancer. In this study, the role of some known small molecular therapeutics has been investigated for their ability to bind with the pre-miRNA target (hsa-mir-155) and thereby to interfere with the Dicer catalyzed miRNA processing. Potential binding and inhibition effects have been demonstrated by some of these analogs. They can be used as leads for further development of potent small molecular miRNA-antagonists.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Maiti M,Nauwelaerts K,Herdewijn P

doi

10.1016/j.bmcl.2011.12.103

subject

Has Abstract

pub_date

2012-02-15 00:00:00

pages

1709-11

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01785-9

journal_volume

22

pub_type

杂志文章

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