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Discovery of new peptide-based catalysts for the direct asymmetric aldol reaction.

Abstract：

:A series of oligo-peptide based catalysts were prepared using Fmoc solid-phase peptide synthesis. It was found that peptides with N-terminal proline residues catalyzed an aldol reaction yielding enantiomeric enriched product. Peptide H-Pro-Glu-Leu-Phe-OH catalyzed the reaction with good activity and moderate enantioselectivity (66% ee). Furthermore, it was shown that an acidic side chain and/or C-termini are essential to catalysis.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Kofoed J,Nielsen J,Reymond JL

doi

10.1016/s0960-894x(03)00498-0

subject

Has Abstract

pub_date

2003-08-04 00:00:00

pages

2445-7

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960894X03004980

journal_volume

13

pub_type

杂志文章

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