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Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

Abstract：

:A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Wan ZK,Lee J,Xu W,Erbe DV,Joseph-McCarthy D,Follows BC,Zhang YL

doi

10.1016/j.bmcl.2006.06.051

subject

Has Abstract

pub_date

2006-09-15 00:00:00

pages

4941-5

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(06)00719-0

journal_volume

16

pub_type

杂志文章

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