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Synthetic ligand promotes gene expression by affecting GC sequence in promoter.

Abstract：

:A naphthyridine carbamate tetramer (NCT8) is a synthetic compound, which selectively binds to nucleic acids containing CGG/CGG sequence. Although NCT8 is a promising compound for a wide range of DNA and RNA based biotechnology such as modulation of specific gene expression, little is known about its behavior in human cells. In the present study, we investigated the changes induced in gene expression by NCT8. Genes differentially expressed in the presence of NCT8 in HeLa cells were identified by whole-transcriptome analysis. The whole-transcriptome analysis showed that NCT8 significantly induced up-regulation of specific genes, whose promoter region has GC-rich sequence.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Matsumoto S,Iida K,Murata A,Denawa M,Hagiwara M,Nakatani K

doi

10.1016/j.bmcl.2017.06.006

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

3391-3394

issue

15

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(17)30608-X

journal_volume

27

pub_type

杂志文章

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