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Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks.

Abstract：

:Novel imidazole frameworks have been identified as potent partial agonists of the alpha(1A) adrenergic receptor, with good selectivity over the alpha(1B), alpha(1D) and alpha(2A) receptor sub-types. Nitrile 28 possessed attractive CNS drug-like properties with good membrane permeability and no P-pg mediated efflux. 28 also possessed excellent solubility, metabolic stability and wide ligand selectivity.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Whitlock GA,Brennan PE,Roberts LR,Stobie A

doi

10.1016/j.bmcl.2009.03.162

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

3118-21

issue

11

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)00486-7

journal_volume

19

pub_type

杂志文章

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