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Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.

Abstract：

:A series of benzotriazole phenyldifluoromethylphosphonic acids were found to be potent PTP-1B inhibitors. Molecular modeling on the X-ray crystal structure of the lead structure led to the design of potent PTP-1B inhibitors that show moderate selectivity against TC-PTP, a very closely related protein tyrosine phosphatase.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Lau CK,Bayly CI,Gauthier JY,Li CS,Therien M,Asante-Appiah E,Cromlish W,Boie Y,Forghani F,Desmarais S,Wang Q,Skorey K,Waddleton D,Payette P,Ramachandran C,Kennedy BP,Scapin G

doi

10.1016/j.bmcl.2003.11.076

subject

Has Abstract

pub_date

2004-02-23 00:00:00

pages

1043-8

issue

4

eissn

0960-894X

issn

1464-3405

pii

S0960894X03012411

journal_volume

14

pub_type

杂志文章

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