Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.

Abstract:

:Drug design efforts in the emerging 2-aminothiazole-4-carboxamide class of CHK1 inhibitors have uncovered specific combinations of key substructures within the molecule; resulting in significant improvements in cell-based activity while retaining a greater than one hundred-fold selectivity against CDK2. The X-ray crystal structure of a complex between compound 39 and the CHK1 protein detailing a 'U-shaped' topology and key interactions with the protein surface at the ATP site is also reported.

journal_name

Bioorg Med Chem Lett

authors

Huang X,Cheng CC,Fischmann TO,Duca JS,Richards M,Tadikonda PK,Reddy PA,Zhao L,Siddiqui MA,Parry D,Davis N,Seghezzi W,Wiswell D,Shipps GW Jr

doi

10.1016/j.bmcl.2013.02.108

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

2590-4

issue

9

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)00295-3

journal_volume

23

pub_type

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