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Novel pyrimidines as acid pump antagonists (APAs).

Abstract：

:A series of pyrimidine derivatives as acid pump antagonists (APAs) was synthesized and the inhibitory activities against H(+)/K(+) ATPase isolated from hog gastric mucosa were determined. After elaborating on substituents at C2 and C4 position of the pyrimidine scaffold, we have observed that the compound 7h is a potent APA with H(+)/K(+) ATPase, IC(50) = 52 nM.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Yoon YA,Park CS,Cha MH,Choi H,Sim JY,Kim JG

doi

10.1016/j.bmcl.2010.08.007

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

5735-8

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(10)01117-0

journal_volume

20

pub_type

杂志文章

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