Abstract:
:A series of 4beta-arylamino-4'-O-demethylepipodophyllotoxins and 4beta-arylaminoepipodophyllotoxins have been synthesized with significant stereoselectivity and improved yields by employing the methanesulphonic acid/sodium iodide reagent system. Compounds NPF. W-68 and other DNA topoisomerase II inhibitors are prepared in good to excellent yields by this method and these are active or more active than etoposide in their inhibition of the human DNA topoisomerase II.
journal_name
Bioorg Med Chem Lettjournal_title
Bioorganic & medicinal chemistry lettersauthors
Kamal A,Laxman N,Ramesh Gdoi
10.1016/s0960-894x(00)00407-8subject
Has Abstractpub_date
2000-09-18 00:00:00pages
2059-62issue
18eissn
0960-894Xissn
1464-3405pii
S0960-894X(00)00407-8journal_volume
10pub_type
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