Facile and efficient one-pot synthesis of 4beta-arylaminopodophyllotoxins: synthesis of DNA topoisomerase II inhibitors (NPF and W-68).

Abstract:

:A series of 4beta-arylamino-4'-O-demethylepipodophyllotoxins and 4beta-arylaminoepipodophyllotoxins have been synthesized with significant stereoselectivity and improved yields by employing the methanesulphonic acid/sodium iodide reagent system. Compounds NPF. W-68 and other DNA topoisomerase II inhibitors are prepared in good to excellent yields by this method and these are active or more active than etoposide in their inhibition of the human DNA topoisomerase II.

journal_name

Bioorg Med Chem Lett

authors

Kamal A,Laxman N,Ramesh G

doi

10.1016/s0960-894x(00)00407-8

subject

Has Abstract

pub_date

2000-09-18 00:00:00

pages

2059-62

issue

18

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(00)00407-8

journal_volume

10

pub_type

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