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Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin.

Abstract：

:A series of NN703 analogues with lysine mimetics combined with naphthyl- or biphenylalanine in the core has been prepared and tested in vitro in a rat pituitary cell based assay and subsequently in vivo in pigs in a single dose at 50 nmol/kg. Re-introduction of certain pharmacophores in the C-terminal of NN703, which were originally removed during optimisation for oral bioavailability, led to unexpectedly potent compounds in vitro as well as in vivo.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Hansen TK,Ankersen M,Raun K,Hansen BS

doi

10.1016/s0960-894x(01)00345-6

subject

Has Abstract

pub_date

2001-07-23 00:00:00

pages

1915-8

issue

14

eissn

0960-894X

issn

1464-3405

pii

S0960894X01003456

journal_volume

11

pub_type

杂志文章

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