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Ionic liquid promoted synthesis, antibacterial and in vitro antiproliferative activity of novel α-aminophosphonate derivatives.

Abstract：

:Ionic liquid ethyl ammonium nitrate is used as an excellent catalyst and solvent for three-component one-pot reaction of an aldehydes, amines and diethylphosphite to form novel α-aminophosphonates at room temperature. Among the various catalysts, the preparation of ethyl ammonium nitrate is an environmental friendly, cost effective and recyclable catalyst. Compounds 4b, 4c, 4d, 4f and 4j were found more potent antibacterials against pathogenic microorganisms. Whereas, compounds 4a, 4g, 4h and 4j inhibits growth of active Escherichia coli NCIM 2645 and Salmonella typhi NCIM 2501. Compound 4j was found a promising antiproliferative agent against A549 and SK-MEL2 human melanoma cell lines.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Dake SA,Raut DS,Kharat KR,Mhaske RS,Deshmukh SU,Pawar RP

doi

10.1016/j.bmcl.2011.02.039

subject

Has Abstract

pub_date

2011-04-15 00:00:00

pages

2527-32

issue

8

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)00223-X

journal_volume

21

pub_type

杂志文章

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