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Different hydroxyl radical scavenging activity of water-soluble beta-alanine C60 adducts.

Abstract：

:Three C(60) derivatives [C(60) (NHCH(2)CH(2)COONa)(n)(H)(n)], n=1, 5, 9] (A, B, C) with different additional number of beta-alanine were synthesized by the control of relative amount of C(60) and beta-alanine added. Hydroxyl radical scavenging activity of the adducts was evaluated in a copper-catalyzed Haber-Weiss reaction by chemiluminescence technology. The 50% inhibition concentrations (IC(50)'s) of A, B, and C were 147.2 micromol/L, 76.3 micromol/L, and 96.2 micromol/L, respectively. The difference should be closely related to the numbers of residual C=C bonds in C(60), steric effect and electron-withstanding effect of amino group especially.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Sun T,Jia Z,Xu Z

doi

10.1016/j.bmcl.2004.01.032

subject

Has Abstract

pub_date

2004-04-05 00:00:00

pages

1779-81

issue

7

eissn

0960-894X

issn

1464-3405

pii

S0960894X0400085X

journal_volume

14

pub_type

杂志文章

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