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Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection.

Abstract：

:The identification and optimization of a series of substituted tetrahydro-beta-carbolines with potent activity against human papillomavirus is described. Structure-activity studies focused on the substitution pattern and chirality of the beta-carboline ring system are discussed. Optimization of these parameters led to compounds with antiviral activities in the low nanomolar range.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Miller JF,Turner EM,Sherrill RG,Gudmundsson K,Spaltenstein A,Sethna P,Brown KW,Harvey R,Romines KR,Golden P

doi

10.1016/j.bmcl.2009.10.123

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

256-9

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(09)01544-3

journal_volume

20

pub_type

杂志文章

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