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Synthesis and acrosin inhibitory activities of substituted ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives.

Abstract：

:A series of novel ethyl 5-(4-aminophenyl)-1H-pyrazole-3-carboxylate derivatives were designed and synthesized and their in vitro acrosin inhibitory activities were evaluated. Most of the compounds exhibited acrosin inhibitory activities. Among them, three compounds (5l, 5n, and 5v) were more potent than that of the control TLCK. These provide a new structural type for the development of novel contraceptive acrosin inhibitory agents.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Qi J,Zhu J,Liu X,Ding L,Zheng C,Han G,Lv J,Zhou Y

doi

10.1016/j.bmcl.2011.07.110

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

5822-5

issue

19

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(11)01056-0

journal_volume

21

pub_type

杂志文章

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