Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.

Abstract:

:A novel series of potent zwitterionic uracil GnRH antagonists were discovered that showed reduced liability for CYP3A4 enzyme inhibition.

journal_name

Bioorg Med Chem Lett

authors

Regan CF,Guo Z,Chen Y,Huang CQ,Chen M,Jiang W,Rueter JK,Coon T,Chen C,Saunders J,Brown MS,Betz SF,Struthers RS,Yang C,Wen J,Madan A,Zhu YF

doi

10.1016/j.bmcl.2008.07.059

subject

Has Abstract

pub_date

2008-08-15 00:00:00

pages

4503-7

issue

16

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00825-1

journal_volume

18

pub_type

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