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Structure-activity studies of quinuclidinone analogs as anti-proliferative agents in lung cancer cell lines.

Abstract：

:We have synthesized and tested novel quinuclidinone analogs to assay the effects on H1299 lung cancer cell lines alone or with gamma-radiation. We have found two series of quinuclidinone analogs that act as anti-cancer agents. Of these, four interesting analogs significantly decreased cell viability in H1299 lung cancer cell lines. Two derivatives decreased cell proliferation in a dose-dependent fashion alone or in the presence of gamma-radiation. Radiosensitization increased when derivative treatment preceded radiation treatment for both derivatives. These preliminary studies show an evidence for both additive and synergistic cytotoxicity for treatment of lung cancer by these novel quinuclidinone analogs.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Malki A,Pulipaka AB,Evans SC,Bergmeier SC

doi

10.1016/j.bmcl.2005.11.085

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

1156-9

issue

5

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(05)01513-1

journal_volume

16

pub_type

杂志文章

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