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Conformational analysis of a covalently cross-linked Watson-Crick base pair model.

Abstract：

:Low-temperature NMR experiments and molecular modeling have been used to characterize the conformational behavior of a covalently cross-linked DNA base pair model. The data suggest that Watson-Crick or reverse Watson-Crick hydrogen bonding geometries have similar energies and can interconvert at low temperatures. This low-temperature process involves rotation about the crosslink CH(2)C(5') (psi) carbon-carbon bond, which is energetically preferred over the alternate CH(2)N(3) (phi) carbon-nitrogen bond rotation.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Jensen EA,Allen BD,Kishi Y,O'Leary DJ

doi

10.1016/j.bmcl.2008.07.113

subject

Has Abstract

pub_date

2008-11-15 00:00:00

pages

5884-7

issue

22

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(08)00891-3

journal_volume

18

pub_type

杂志文章

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