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Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.

Abstract：

:We designed and synthesized an estrogen receptor (ER) down-regulator (5), which is a derivative of tamoxifen with a long alkyl side chain. Compound 5 effectively reduced ER protein levels in MCF-7 cells and had an antagonistic effect.

journal_name

Bioorg Med Chem Lett

journal_title

Bioorganic & medicinal chemistry letters

authors

Shoda T,Okuhira K,Kato M,Demizu Y,Inoue H,Naito M,Kurihara M

doi

10.1016/j.bmcl.2013.11.078

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

87-9

issue

1

eissn

0960-894X

issn

1464-3405

pii

S0960-894X(13)01369-3

journal_volume

24

pub_type

杂志文章

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